Literature
- The following papers provide an overview of the SPAMS research that was performed at Lawrence Livermore National Laboratory:
Fergenson, D. P. et al. (2004). "Reagentless detection and classification of individual bioaerosol particles in seconds." Analytical Chemistry 76(2): 373-378. DOI:10.1021/ac034467e
Steele, P. T. et al. (2003). "Laser power dependence of mass spectral signatures from individual bacterial spores in bioaerosol mass spectrometry." Analytical Chemistry 75(20): 5480-5487. DOI: 10.1021/ac051329b
- These papers demonstrate the detailed characterization of the small molecules found in Bacillus spores. The small molecular composition of microorganisms is surprisingly informative.
Russell, S. C. et al. (2004). "Toward understanding the ionization of biomarkers from micrometer particles by bio-aerosol mass spectrometry." Journal of the American Society for Mass Spectrometry 15(6): 900-909. DOI: 10.1016/j.jasms.2004.02.013
Czerwieniec, G. A. et al. (2005). "Stable isotope labeling of entire Bacillus atrophaeus spores and vegetative cells using bioaerosol mass spectrometry." Analytical Chemistry 77(4): 1081-1087. DOI: 10.1021/ac0488098
Srivastava, A. et al. (2005). "Comprehensive Assignment of Mass Spectral Signatures from Individual Bacillus atrophaeus Spores in Matrix-Free Laser Desorption/Ionization Bioaerosol Mass Spectrometry." Analytical Chemistry 77(10): 3315-3323. DOI: 10.1021/ac048298p
- These papers describe various applications of a SPAMS. The first three papers describe the application of a SPAMS 3.0 to pharmaceutical inhalation analytics. Other papers describe broad spectrum threat detection as well as the detection of specific agents of concern.
Fergenson, D.P. et al. "Real-Time Determination of Aerodynamic Particle Size Profiles and the Presence/Co-Presence of Active Ingredients in Inhalational Pharmaceutical Products Using a SPAMS 3." RDD Europe 2013, Vol 2, pp 317-320.
- Fergenson, D.P. et al. (2014). “Real-Time Inhalation Analytics Using Single Particle Aerosol Mass Spectrometry (SPAMS).” Respiratory Drug Delivery 2014 Vol 1, pp 259-266. http://www.rddonline.com/publications/article.php?ArticleID=1908&return=1
- Susz, A. et al. (2014) "New Determination Method of Aerodynamic Diameter Size Distribution in Dry Powder Inhalers using SPAMS 3.0.“ Respiratory Drug Delivery 2014 Vol 2, pp 515-518. http://www.rddonline.com/publications/article.php?ArticleID=1957&return=1
- Steele, P.T. et al. (2008). “Autonomous, Broad-Spectrum Detection of Hazardous Aerosols in Seconds.” Analytical Chemistry 80 (12):4583-4589. DOI: 10.1021/ac8004428
- Martin, A.N. et al. (2007). “Single Particle Aerosol Mass Spectrometry for the Detection and Identification of Chemical Warfare Agent Simulants.” Analytical Chemistry 79(16): 6368-6375. DOI: 10.1021/ac070704s
- Martin, A.N. et al. (2007). "The non-destructive identification of solid over-the-counter medications using single particle aerosol mass spectrometry." Rapid Communications in Mass Spectrometry 21(23): 3561-3568. DOI: 10.1002/rcm.3248
- Tobias, H. J. et al. (2005). "Bioaerosol mass spectrometry for rapid detection of individual airborne Mycobacterium tuberculosis H37Ra particles." Applied and Environmental Microbiology 71(10): 6086-6095. DOI: 10.1128/AEM.71.10.6086-6095.2005
- Adams, K.L. et al. (2008). "Reagentless Detection of Mycobacteria tuberculosis H37Ra in Respiratory Effluents in Minutes." Analytical Chemistry 80(14): 5350-5357. DOI: 10.1021/ac8002825
